The mechanism of Robinson annelation (also known as Robinson annulation) involves the sequential process of a Michael addition-aldol reaction leading to a new six-membered ring. The formation of a stable enolate occurs first as shown below, here of a 1,3-diketone:
Click the different stages to view 3D models of the reaction:
Below are shown the three stages of the Robinson annelation mechanism.
Step 1: Conjugate addition
Step 3: E1cb dehydration
We are sorry that this page was not useful for you!
Let us improve this page!
Tell us how we can improve this page (in your own language if you prefer)? If you would like a response, please include your email address e.g. [email protected]