Spiroketal Formation – Stereoelectronic Effects

Spiroketal formation

Click the structures and reaction arrows in sequence to view the 3D models and animations respectively

The usual mechanism for acetal formation is followed and initially the spiroketal forms the axial-equatorial (ax-eq) conformation which equilibrates to the more stable chair-chair axial-axial (ax-ax) conformation.

J. E. Aho, P. M. Pihko and T. K. Rissa, Chem. Rev., 2005, 105, 4406–4440.

F. Perron and K. F. Albizati, Chem. Rev., 1989, 89, 1617–1661.


How useful was this page?

Click on a star to rate it!

Average rating / 5. Vote count:

No votes so far! Be the first to rate this page.

As you found this page useful...

Follow us on social media!

We are sorry that this page was not useful for you!

Let us improve this page!

Tell us how we can improve this page (in your own language if you prefer)? If you would like a response, please include your email address e.g. [email protected]

Provided by the