Wittig reaction

The Wittig reaction is the overall substitution of a C=O bond to a C=C bond. It is a reaction between a cabonyl compound (aldehyde or ketone only) and a species known as a phosphonium ylid. An ylid is a species with a positive and negative charges on adjacent atoms. A phosphonium ylid carries its positive charge on phosphorus. ‘Click’ on the image below to view the 3D mechanism for the formation of one such phosphonium ylid:

Below is an example of a typical Wittig reaction. The phosphonium ylid is treated with the carbonyl compound (cyclohexanone) to give the alkene in 85% yield. ‘Click’ on the image below to view the 3D mechanism for the formation of the alkene:

P. A. Byrne and D. G. Gilheany, Chem. Soc. Rev., 2013, 42, 6670.

 

How useful was this page?

Click on a star to rate it!

Average rating / 5. Vote count:

No votes so far! Be the first to rate this page.

As you found this page useful...

Follow us on social media!

We are sorry that this page was not useful for you!

Let us improve this page!

Provided by the