Oxidation of dihydropyridine by DDQ

Sn2

Click the structures and reaction arrows in sequence to view the 3D models and animations respectively

Dihydropyridines are oxidised by various oxidants such as quinones e.g. 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) by transferring a hydride from the pyridine to DDQ. Subsequent proton exchange leads to the formation of two aromatic products (quinol and pyridine ring). This is the last stage of the Hantzsch pyridine synthesis.

X.-Q. Zhu, B.-J. Zhao and J.-P. Cheng, J. Org. Chem., 2000, 65, 8158–8163.

4
(2)

How useful was this page?

Click on a star to rate it!

Average rating 4 / 5. Vote count: 2

No votes so far! Be the first to rate this page.

As you found this page useful...

Follow us on social media!

We are sorry that this page was not useful for you!

Let us improve this page!

Tell us how we can improve this page (in your own language if you prefer)?

Provided by the