Oxidation of dihydropyridine by DDQ



Click the structures and reaction arrows in sequence to view the 3D models and animations respectively

Dihydropyridines are oxidised by various oxidants such as quinones e.g. 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) by transferring a hydride from the pyridine to DDQ. Subsequent proton exchange leads to the formation of two aromatic products (quinol and pyridine ring). This is the last stage of the Hantzsch pyridine synthesis.

X.-Q. Zhu, B.-J. Zhao and J.-P. Cheng, J. Org. Chem., 2000, 65, 8158–8163.



How useful was this page?

Click on a star to rate it!

Average rating 4 / 5. Vote count: 2

As you found this page useful...

Follow us on social media!

We are sorry that this page was not useful for you!

Let us improve this page!

Provided by the