Nucleophilic attack by hydride

5
(2)

Click the structures and reaction arrows in sequence to view the 3D models and animations respectively

Hydride addition to a carbonyl group can be achieved with compounds containing nucleophilic hydrogen atoms, and is known as a reduction reaction. One such compound is sodium borohydride. The reaction involves the carbonyl group behaving as the electrophile, and a pair of electrons from one of the B-H bonds being transferred to the carbon atom of the C=O group. The reaction can be regarded as a ‘hydride transfer’.

D. C. Wigfield, Tetrahedron, 1979, 35, 449–462.

How useful was this page?

Click on a star to rate it!

Average rating 5 / 5. Vote count: 2

As you found this page useful...

Follow us on social media!

We are sorry that this page was not useful for you!

Let us improve this page!

Provided by the