Synthesis of Pyrimidine

Sn2

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Reaction of a 1,3-diketone and an amidine gives a six-membered aromatic heterocycle known as a pyrimidine. As the nucleophile contains a double bond, an aromatic heterocycle is formed directly without the need for oxidation.

A. R. Katritzky, D. L. Ostercamp and T. I. Yousaf, Tetrahedron, 1987, 43, 5171–5186.

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