Synthesis of Pyrimidine

5
(1)

Sn2

Click the structures and reaction arrows in sequence to view the 3D models and animations respectively

Reaction of a 1,3-diketone and an amidine gives a six-membered aromatic heterocycle known as a pyrimidine. As the nucleophile contains a double bond, an aromatic heterocycle is formed directly without the need for oxidation.

A. R. Katritzky, D. L. Ostercamp and T. I. Yousaf, Tetrahedron, 1987, 43, 5171–5186.

 

 

How useful was this page?

Click on a star to rate it!

Average rating 5 / 5. Vote count: 1

As you found this page useful...

Follow us on social media!

We are sorry that this page was not useful for you!

Let us improve this page!

Provided by the