Robinson annelation (Step 3: E1cB dehydration)

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The final step is the dehydration of the aldol product and an E1cb mechanism that involves the carbonyl group as in a standard aldol reaction dehydration. Another enolate must form in the same position as in the previous step.

Back to Robinson annelation summary

R. E. Gawley, Synthesis (Stuttg)., 1976, 1976, 777–794.

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