The Hantzsch synthesis is a four-component reaction between an aldehyde, two equivalents of a β-ketoester and ammonia, followed by oxidation to give a pyridine-3,5-dicarboxylate. Subsequent decarboxylation gives the corresponding pyridines.
‘Click’ the different stages to view the 3D models of the reaction:
H. G. O. Alvim, E. N. da Silva Júnior and B. A. D. Neto, RSC Adv., 2014, 4, 54282–54299.
We are sorry that this page was not useful for you!
Let us improve this page!
Tell us how we can improve this page (in your own language if you prefer)? If you would like a response, please include your email address e.g. [email protected]