Endiandric Acid Cascade


Now that you have an idea of how pericyclic reactions in general work, this set of pages demonstrate how to spot such reactions in succession. These are Tandem Organic reactions, which can occur in Nature. These reactions are often difficult to spot so each step of the tandem reaction sequence is shown individually. The set of Endiandric Acids which are the result of either tandem electrocyclic reactions or tandem electrocyclic followed by a cycloaddition step are shown.

All of these steps are intramolecular and follow the Woodward-Hoffman rules.


‘Click’ the different stages to view the 3D models of the reaction:


Final Year Project 2013: Ilona Blee

K. C. Nicolaou, N. A. Petasis, R. E. Zipkin and J. Uenishi, J. Am. Chem. Soc., 1982, 104, 5555–5557.

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