Click the structures and reaction arrows in sequence to view the 3D models and animations respectively
This shows the tradtional mechanism for forming a pyrrole ring using a 1,4-diketone and ammonia. The hydroxyl groups are removed as water in two separate dehydration steps, forming enamines in two of the intermediates.
A new mechanism, which does not require enamine formation, has been proposed based on a study using Density Functional Theory.
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