The first of Sharpless’s reactions is the oxidation of an alkene by asymmetric epoxidation. By adding a chiral ligand to the titanium catalyst the reaction becomes asymmetric. The ligand that works best is L-(+)-diethyl tartrate. The active complex is believed to be two titanium atoms bridged by two tartrate ligands.
Methyl esters have been used in the animation for simplicity.
We are sorry that this page was not useful for you!
Let us improve this page!
Tell us how we can improve this page (in your own language if you prefer)? If you would like a response, please include your email address e.g. [email protected]