Citral is a compound which can be used in the synthesis of vitamin A. This industrial synthesis is made up of two different [3,3]-sigmatropic rearrangements done in sequence.
The first is a Claisen rearrangement which involves an oxygen in the chair-like transition state. More details of the Claisen rearrangement can be found here. The second part of the single step reaction is a Cope-rearrangement, in which only carbons are involved in the chair-like transition state. These two reactions happen in succession when the two starting materials are heated together, and the reaction is driven by formation of a conjugated carbonyl group in the product.
Final Year Project 2013: Ilona Blee
We are sorry that this page was not useful for you!
Let us improve this page!
Tell us how we can improve this page (in your own language if you prefer)? If you would like a response, please include your email address e.g. [email protected]