1,3-Dipolar Cycloaddition Formation of a Simple Isoxazole

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1,3-Dipolar Cycloaddition

Formation of a Simple Isoxazole

The nitrile oxide is unstable so it is made in situ by reaction of hydroxylamine with an aldehyde. Click here to view this reaction. The nitrile oxide then reacts with the alkyne to produce the isoxazole.

F. Heaney, European J. Org. Chem., 2012, 2012, 3043–3058.

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