Cyclic acetal formation

Click the structures and reaction arrows in sequence to view the 3D models and animations respectively

Cyclic acetals are more stable towards hydrolysis than acyclic ones, they are also much easier to make. Cyclic acetals are readily formed by the reaction of two molecules, a ketone and a diol. The reaction produces two products, the acetal plus water, so the usually unfavourable entropy of acetal formation is not a factor. Formation is also kinetically favoured because the intramolecular ring-closing reaction is fast.

S. Krompiec, M. Penkala, K. Szczubiałka and E. Kowalska, Coord. Chem. Rev., 2012, 256, 2057–2095.

()

How useful was this page?

Click on a star to rate it!

Average rating / 5. Vote count:

No votes so far! Be the first to rate this page.

As you found this page useful...

Follow us on social media!

We are sorry that this page was not useful for you!

Let us improve this page!

Tell us how we can improve this page (in your own language if you prefer)? If you would like a response, please include your email address e.g. [email protected]

Provided by the