Base-Catalysed Bromination Summary

Base-Catalysed Bromination of Ketones

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The hydroxide removes a proton from the ketone to form an enolate anion. The enolate anion attacks the bromine molecule yielding a mono-substituted bromoketone. The reaction continues until the tribromoketone is formed. The hydroxide then attacks directly at the carbonyl and a tribromomethyl anion is lost.

E. Tapuhi and W. P. Jencks, J. Am. Chem. Soc., 1982, 104, 5758–5765.


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