Synthesis of an intermediate for Crixivan by the Ritter reaction

4
(1)
Sn2

Click the structures and reaction arrows in sequence to view the 3D models and animations respectively

The epoxide is protonated and the epoxide then opens to yield a stabilised cation. The acetonitrile attacks the cation (Ritter) and then a 5-membered ring is formed due to the hydroxyl group attacking the triple bond intramolecularly.

P. J. Reider, Chimia (Aarau)., 1997, 51, 306–308.

 

 

How useful was this page?

Click on a star to rate it!

Average rating 4 / 5. Vote count: 1

As you found this page useful...

Follow us on social media!

We are sorry that this page was not useful for you!

Let us improve this page!

Provided by the