Robinson annelation (Step 2: Intramolecular aldol reaction)

Click the structures and reaction arrows in sequence to view the 3D models and animations respectively

The next step is the formation of a new enolate on the other side of the ketone from the first. Note that the original enolate, the intermediate in the conjugate addition, can cyclize to give only an unstable four-membered ring so this cyclization would be reversible. The next intermediate, the aldol product, is often isolated from Robinson annelations.

Back to Robinson annelation summary

R. E. Gawley, Synthesis (Stuttg)., 1976, 1976, 777–794.


How useful was this page?

Click on a star to rate it!

Average rating / 5. Vote count:

No votes so far! Be the first to rate this page.

As you found this page useful...

Follow us on social media!

We are sorry that this page was not useful for you!

Let us improve this page!

Tell us how we can improve this page (in your own language if you prefer)? If you would like a response, please include your email address e.g. [email protected]

Provided by the