Mannich reaction (Enone formation)

0
(0)

Click the structures and reaction arrows in sequence to view the 3D models and animations respectively

The Mannich products can be converted to enones. The most reliable method for making the enone is to alkylate the Mannich base with MeI and then treat the ammonium salt with base. Enolate ion formation leads to an E1cB reaction rather like the dehydration of aldols, but with a better leaving group.

Back to Mannich summary

T. F. Cummings and J. R. Shelton, J. Org. Chem, 1960, 25, 419–423.

H. G. O. Alvim, E. N. da Silva Júnior and B. A. D. Neto, RSC Adv., 2014, 4, 54282–54299.

 

 

How useful was this page?

Click on a star to rate it!

Average rating 0 / 5. Vote count: 0

No votes so far! Be the first to rate this page.

As you found this page useful...

Follow us on social media!

We are sorry that this page was not useful for you!

Let us improve this page!

Tell us how we can improve this page (in your own language if you prefer)?

Provided by the