Mitsunobu Reaction Stage 4

NOTE: Important charges and non-bonding electrons are shown throughout the animation except during the transition state phase.

^{Click the structures and reaction black arrows in sequence to view the 3D models and animations respectively}

Finally, the anion of the nucleophile (carboxylate anion) completes an S_N2 reaction with the oxyphosphonium derivative forming the required ester product and a phosphine oxide.

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T. Y. S. But and P. Toy, Chem. - An Asian J., 2007, 2, 1340–1355.