Mitsunobu Reaction Stage 4

NOTE: Important charges and non-bonding electrons are shown throughout the animation except during the transition state phase.

Click the structures and reaction black arrows in sequence to view the 3D models and animations respectively

Finally the anion of the nucleophile (carboxylate anion) completes an SN2 reaction with the oxyphosphonium derivative forming the required ester product and a phosphine oxide.

Back to Mitsunobu Summary

T. Y. S. But and P. Toy, Chem. - An Asian J., 2007, 2, 1340–1355.

 

 

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