Dimedone synthesis

Conjugate addition followed by intramolecular acylation

Base catalysed ester hydrolysis, protonation and thermal decarboxylation.

Click the structures and reaction arrows in sequence to view the 3D models and animations respectively

X. Jin, W. Xu, J. Yang, J. Lu, Y. Fu, L. Xie, Q. Zhu and W. Dong, Tetrahedron Lett., 2015, 56, 6287–6289.

 

Provided by the