Knorr Pyrrole Synthesis

Sn2

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This synthesis is so important, it was given the name of its inventor, Ludwig Knorr.

In this reaction, the amino group forms an imine with one of the diketone carbonyl groups. The enamine intermediate then cyclizes onto the other ketone carbonyl and water is removed to form the aromatic heterocycle.

A. R. Katritzky, D. L. Ostercamp and T. I. Yousaf, Tetrahedron, 1987, 43, 5171–5186.

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