Pyrrole-Vilsmeier-Hydrolysis of an Iminium Salt

NOTE: Important charges and non-bonding electrons are shown throughout the animation except during the transition phase

Click the structures and reaction arrows to view the 3D models and animations respectively

Hydrolysis of the iminium salt is carried out using Na2CO3 and water. This is a particularly useful method as it removes any acid formed and also adds a formyl group. The Vilsmeier reaction is useful in the formylation of a wide range of electron-rich heterocycles.

Back to The Vilsmeier Reaction

J. Muzart, Tetrahedron, 2009, 65, 8313–8323.


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