Intramolecular aldol reactions (Six-membered ring formation)

Click the structures and reaction arrows in sequence to view the 3D models and animations respectively

In practice, only the less strained six-membered ring is formed, and when treated with sulfuric acid, the enone can be isolated in an 85% yield.

Back to intramolecular aldol summary

P. Hammar, C. Ghobril, C. Antheaume, A. Wagner, R. Baati and F. Himo, J. Org. Chem., 2010, 75, 4728–4736.

W. Gati and H. Yamamoto, Acc. Chem. Res., 2016, 49, 1757–1768.

 

 

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