Intramolecular aldol reactions (Eight-membered ring formation)

Click the structures and reaction arrows in sequence to view the 3D models and animations respectively

As mentioned previously, five- or six-membered rings are preferred to those of medium sized rings, so the reaction shown above will not occur.

Back to intramolecular aldol summary

P. Hammar, C. Ghobril, C. Antheaume, A. Wagner, R. Baati and F. Himo, J. Org. Chem., 2010, 75, 4728–4736.

W. Gati and H. Yamamoto, Acc. Chem. Res., 2016, 49, 1757–1768.

 

 

How useful was this page?

Click on a star to rate it!

Average rating / 5. Vote count:

As you found this post useful...

Follow us on social media!

We are sorry that this page was not useful for you!

Let us improve this page!

Provided by the