Aldol reaction of cyclopentanone (Step 1)

Step 1 – Acid catalysed enolization

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The first stage of this reaction is the acid-catalysed enolization step. Once the oxygen atom has been protonated, a hydrogen atom is lost from the ring structure to form the enol.

Back to cyclopentanone aldol summary

D. S. Noyce and W. A. Pryor, J. Am. Chem. Soc., 1955, 77, 1397–1401.

C. L. Perrin and K.-L. Chang, J. Org. Chem., 2016, 81, 5631–5635.

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