Third Bromination Step – Base

Sn2

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The reaction is started by the removal of a proton by hydroxide to yield an enolate. The enolate then attacks the bromine molecule to give the tri-substituted bromoacetone and the bromide anion.

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E. Tapuhi and W. P. Jencks, J. Am. Chem. Soc., 1982, 104, 5758–5765.

 

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