Second Bromination Step – Base

Sn2

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The presence of the bromine further acidifies the enolisable proton so deprotonation occurs easily to yield an enolate. The enolate then attacks the bromine molecule as before to give the di-substituted bromoacetone and the bromide anion.

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E. Tapuhi and W. P. Jencks, J. Am. Chem. Soc., 1982, 104, 5758–5765.

 

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