Click the structures and reaction arrows in sequence to view the 3D models and animations respectively
The reaction goes via an enamine, which attacks the aldehyde Re-face to form the R-product. In the transition state the isopropyl group is pseudoequatorial to minimise the 1,3-diaxial repulsions from the axial methyl group alpha to the nitrogen. This forms the R-aldol product.
We are sorry that this page was not useful for you!
Let us improve this page!
Tell us how we can improve this page (in your own language if you prefer)?