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DC-174 is a drug molecule containing a morpholine ring (red) with a sulfonylcyclopropane substitution (orange), a hydroxamate substitution (green) and a sulfonyl-4-methoxybenzene substitution (blue). It was designed to improve on earlier drug called XL-784 and shows improved potency, metabolic stability and solubility. This drug target only takes 30 minutes for drug levels to reach their peak following oral dosage but has a short half-life (the time it takes for the amount of drug in the body to reduce by half) of 1.41 hours. This was improved by administering a second dose 1.5 hours after the first which helped maintain effective drug levels for longer.
For more information, visit the degree page for DC-174
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