Binding sites in the Transcription Factors CueR and ZntR

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Comparison of the (a) Cu-binding and (b) Zn-binding sites in the respective transcription factors CueR and ZntR. Note how Cu(I) is recognized by a linear binding site (to two cysteines) whereas Zn is recognized by an arrangement of Cys and His ligands that binds two Zn(II) atoms together with a bridging phosphate group.