Synthesis of Pyrimidine


Click the structures and reaction arrows in sequence to view the 3D models and animations respectively

Reaction of a 1,3-diketone and an amidine gives a six-membered aromatic heterocycle known as a pyrimidine. As the nucleophile contains a double bond, an aromatic heterocycle is formed directly without the need for oxidation.

A. R. Katritzky, D. L. Ostercamp and T. I. Yousaf, Tetrahedron, 1987, 43, 5171–5186.



Provided by the