Diastereoselectivity Chelate Cram Addition

Organomagnesium addition to alpha-alkoxy ketones

diastereoisomer

Me2Mg chelates if R is small and the major product is produced via addition to the less hindered face of the chelated intermediate. Chelation also increases the rate of addition.

Link to zinc borohydride chelation-controlled reduction

()

How useful was this page?

Click on a star to rate it!

Average rating / 5. Vote count:

No votes so far! Be the first to rate this page.

As you found this page useful...

Follow us on social media!

We are sorry that this page was not useful for you!

Let us improve this page!

Tell us how we can improve this page (in your own language if you prefer)? If you would like a response, please include your email address e.g. [email protected]

Provided by the