Coordination of Pt causes bending of the DNA helix

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Structure of a complex formed between the Pt(NH3)2 fragment from cisplatin and two adjacent guanine bases on an oligonucleotide.

Left: The square-planar ligand arrangement around the Pt atom. Right: Coordination of Pt causes bending of the DNA helix.

 

Click the button to show the square-planar ligand arrangement around the Pt atom.

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