Endo-trig reactions (6-endo-trig)

Click the structures and reaction arrows in sequence to view the 3D models and animations respectively

Lengthening the chain even by just one carbon as shown here, allows the endo-trig cyclization to occur. It is a perfectly straightforward 6-endo-trig cyclization for which orbital overlap presents no problem.

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K. Gilmore and I. V. Alabugin, Chem. Rev., 2011, 111, 6513–6556.

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