Synthesis of Aromatic Heterocycles

Synthesis of Pyridazine

Disconnection of pyridazines gives a molecule of hydrazine, and a 1,4-diketone with an alkene in the 2,3-position. A functional group addition , FGA, disconnection gives us the 1,4-diketone.

The strategy adopted in the synthesis is reaction of hydrazine with the 1,4-diketone to give dihydropyridazine. Oxidation of the dihydropyridazine then gives the pyridazine. Carrying out oxidation at this point avoids a cis double bond problem.

Background Colour:

Sn2

Click the structures and reaction arrows in sequence to view the 3D models and animations respectively

 

 

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