Scan along the baseline to move rapidly among the models, or click on a point to view a specific conformation (be careful not to disturb the baseline in this case!)

Click on the lowest point on the graph to view the most stable conformation.


This reaction is the second step of the Mukaiyama aldol reaction, in which the SiH3 group acts a proton equivalent. The silyl group can be removed by an intramolecular hydrolysis reaction, using a fluoride from the BF3 Lewis acid:

The energy plot shows that the silicon pentacoordinate intermediate is formed at an energy minimum and the maximum energy point is the transition state for the energy minimisation of the product, to give the more favoured conformation.