Six-membered ring formation - aldol

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In practice, only the less strained six-membered ring is formed, and when treated with sulfuric acid, the enone can be isolated in an 85% yield.

Back to intramolecular aldol summary

P. Hammar, C. Ghobril, C. Antheaume, A. Wagner, R. Baati and F. Himo, J. Org. Chem., 2010, 75, 4728–4736.

W. Gati and H. Yamamoto, Acc. Chem. Res., 2016, 49, 1757–1768.