Acid catalysed aldol addition Tutorial

Acid catalysed aldol addition Self Assessment Activity

Tutorial and Self Assessment AvailableStep 2 - Acid catalysed aldol addition

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Enols are less nucleophilic than enolates, but this reaction occurs because the electrophilic carbonyl component is protonated. Following deprotonation of the carbonyl oxygen, the aldol product is formed, which in this case is a tertiary alcohol.

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D. S. Noyce and W. A. Pryor, J. Am. Chem. Soc., 1955, 77, 1397–1401.

C. L. Perrin and K.-L. Chang, J. Org. Chem., 2016, 81, 5631–5635.