Mitsunobu Reaction Stage 1

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NOTE: Important charges and non-bonding electrons are shown throughout the animation except during the transition state phase.

In this initial step a nucleophilic attack is made on the azoformaldehyde to produce a anion intermediate that can be stabilised by one of the formaldehyde groups.

Onto Mitsunobu Stage 2

Back to Mitsunobu Summary

Click the structures and reaction black arrows in sequence to view the 3D models and animations respectively