Mitsunobu Reaction Stage 1

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NOTE: Important charges and non-bonding electrons are shown throughout the animation except during the transition state phase.

In this initial step a nucleophilic attack is made on the azoformaldehyde to produce a anion intermediate that can be stabilised by one of the formaldehyde groups.

Onto Mitsunobu Stage 2

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Click the structures and reaction black arrows in sequence to view the 3D models and animations respectively

T. Y. S. But and P. Toy, Chem. - An Asian J., 2007, 2, 1340–1355.