Scan along the baseline to move rapidly among the models, or click on a point to view a specific conformation (be careful not to disturb the baseline in this case!)

Click on the lowest point on the graph to view the most stable conformation.


This energy profile shows the how the potential energy varies with the change in ring conformation, from chair-chair to boat-chair. The potential energy is higher when the molecule is in an unfavourable conformation due to sterics and low when the molecule is in a more favourable conformation. In this example the curve reaches a maximum when the ring opens up to change conformation.

In the minimum energy conformation the two rings are in a chair-chair conformation, whereas in the higher energy conformation one of the rings is in a boat conformation which is not sterically favourable.

Mechanism for the Formation of this Spiroketal